MSD Intern - Analytical Chemistry PATS 

Netherlands, North Brabant 

860249586

Job Description

Your internship assignment
Active pharmaceutical ingredients (APIs) are often administered in a solid form; e.g., as a tablet or capsule. To achieve the desired bioavailability of the drug, its rate of dissolution is of great importance. The dissolution rate of a drug product can be affected by many parameters such as the particle size, temperature, pH, presence of excipients, stirring speed, etc. As a baseline, it is valuable to know the dissolution rate of the pure API itself, whilst eliminating as many external parameters as possible: the intrinsic dissolution rate. The intrinsic dissolution rate is defined as the rate of dissolution of a pure API when the surface area, stirring speed, pH and ionic strenth of the dissolution medium are kept constant.

The scope of this internship is to introduce intrinsic dissolution testing as an additional characterization tool for APIs. The department features a SOTAX dissolution instrument, and UV-Vis and HPLC instruments for the analysis of the data.

Your responsibilities
Perform a background study on the application of intrinsic dissolution as a characterization tool for APIs

• Introduce intrinsic dissolution testing to the solid state characterization team in an informative presentation

• Perform initial dissolution tests and analyze the results with e.g., HPLC and UV-Vis

• Develop a general method for the sample preparation, execution and result interpretation of intrinsic dissolution testing

• Evaluate the results and suggest adjustments

• Providing a fresh perspective within the department: your opinion matters!

The described tasks form the basic package and will often be performed independently after a proper training and learning period. These tasks may be supplemented with other projects and/or tasks on your own initiative or at the request of the organization.

What is required

• A 4th year bachelor (HBO) or master student in analytical chemistry

• You are trained to work safely and effectively in a laboratory environment

• You are enthusiastic about analytical characterization techniques for APIs in the pharmaceutical industry

• You have (some) knowledge about HPLC analysis and/or dissolution (preferred)

• You are searching for an internship where you have the freedom to take initiative

• You are available for a period of at least 4 – 6 months for 5 days a week.

What we offer

• The chance to gain experience in the pharmaceutical industry

• An opportunity to showcase yourself for potential opportunities after your internship period

• A challenging and dynamic work environment with plenty of room for personal development and initiative

• Good guidance from an experienced specialist

• A gross monthly internship allowance of €500,- based on a 40-hour workweek

Current Contingent Workers apply

Intern/Co-op (Fixed Term)

Not Applicable

*A job posting is effective until 11:59:59PM on the dayBEFOREthe listed job posting end date. Please ensure you apply to a job posting no later than the dayBEFOREthe job posting end date.

A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.