MSD Senior Scientist Protein Structural Chemistry London Discovery 

United Kingdom, England, London 

590744953

Job Description

What you will do:

• You will be responsible for all aspects of the experimental process from sample preparation and data collection through data processing, structure determination.
• Communicate effectively with all key stakeholders with the results of structural analyses.
• Proactively participate in collaboration with colleagues in Modelling & Informatics, Discovery Chemistry, Screening and Compound Profiling, and Mass Spectrometry and Biophysics.
• Identify and manage internal and external scientific partnerships, as necessary.
• Drive productive and collaborative interactions with other members of our global, cross-functional department are required in this role.
• Ensure inclusive and collaborative use of internal expertise and resources.
• The successful candidate is expected to foster and contribute to a diverse workforce where colleagues and partners feel comfortable bringing their unique perspectives to work.
• Active interaction with the external scientific community to continually improve scientific understanding, including presentations at external meetings.

Education:

• Ph.D. in structural biology, biochemistry, or related discipline and relevant experience in a drug discovery setting within the pharmaceutical industry or CRO environment.

Required Experience And Skills:

• Demonstrated experience in a broad range of activities for X-ray crystallography, including crystallisation screening and optimisation, crystal harvesting, data collection, and structure determination, and /or
• Demonstrated experience in a broad range of activities for atomic resolution single particle CryoEM, including sample preparation, data collection, image processing and structure determination.
• Excellent written and oral communication skills that enhance team-based progress and application of those skills both within and outside the department to ensure the maximum understanding of program status for therapeutic area project teams and management.
• Demonstrated organisational skills.
• Ability to work effectively and flexibly within timelines.

• Ability and track record of preparing peer-reviewed publications.

Preferred Experience And Skills:

• Experience with structure determination of small molecule protein complexes and multi-subunit protein complexes.
• Experience with fragment-based lead identification, including primary X-ray fragment screening.
• Experience with automation for x-ray crystallography (Mosquito, NT8, etc.).
• In-depth knowledge of current biophysical and functional characterisation methods (e.g. SPR, thermal shift, ligand-binding, and calorimetric assays) to guide construct design and optimisation.
• Experience using computational tools for protein engineering and design.
• Experience with scientific programming (e.g. Python) and interest in the application of computational tools to answer structural biology questions.
• Ability to manage multiple projects and subsequent prioritisation.

Current Contingent Workers apply

Not Applicable

*A job posting is effective until 11:59:59PM on the dayBEFOREthe listed job posting end date. Please ensure you apply to a job posting no later than the dayBEFOREthe job posting end date.

10/07/2024

A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.