Job Summary (Primary function)
Principal/Sr. Principal Investigator, AI driven Early Discovery Chemistry designs and synthesizes novel compounds that meet nomination criteria.
Essential Functions of the Job (Key responsibilities)
- Designs novel core structures/key structural elements for a new project based on HTS leads or published literature compounds.
- Coordinates efforts with CROs for the acquisition and/or synthesis of compounds to advance early discovery programs.
- Drives research projects, demonstrates the ability to formulate hypothesis based on experimental SAR data, proposes strategies and designs novel molecular targets to solve key medicinal chemistry issues related to potency, selectivity and ADME properties.
- Analyze FTO search report and provide suitable data for patent applications (including a well-documented laboratory notebook).
- Meets inventorship criteria as co-inventor on multiple patent applications.
- Present research results clearly to the department, other disciplines and at outside scientific conference.
- Design/conduct organic chemistry experiments to develop and optimize the synthesis of novel compounds.
Qualifications (Minimal acceptable level of education, work experience, and competency)
- Ph.D. in Organic Chemistry or equivalent experience.
- 3 years of related medicinal chemistry experience.
- Understands basic patent law.
- Successful track record of significant contributions to the understanding of the structure activity relationships and ADME data for multiple discovery programs that lead to the identification of clinical candidate(s).
- Life-long learner: leverage extensive use of the literature to increase knowledge base in all aspects of medicinal and organic chemistry.
- Follow the safety rules and maintains a safe working environment.
- Team player: able to work with others in their group, department and company towards the common goal of inventing novel medicines and positively influences the culture of the group.
Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.
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