Job Summary (Primary function)
The Sr Research Scientist, DMB is responsible for the DMPK support of discovery and/or development projects and may include conducting in vitro ADME assays, biotransformation,
transporter work, bioanalytical method validation, and bioanalysis of study samples utilizing LC-MS/MS.
Essential Functions of the Job (Key responsibilities)
- Conduct routine cell culture procedures, including cell line maintenance, expansion, plating and cryopreservation.
- Perform routine laboratory tasks, including reagent preparation, analytical standard preparation, routine equipment maintenance, and supply management.
- Collaborate with team members on large-scale cell preparation and maintenance for high throughput screening studies.
- Perform DMPK/ADME in vitro assays including cell-based permeability (e.g. Caco-2), PAMPA, protein binding, substrate and inhibition drug transporter assays, etc. The cell-based assays are supporting both high throughput screening and more definitive/detailed studies meant to support kinetic and drug-drug interaction analyses.
- Must have excellent sterile laboratory technique and be capable of establishing and maintaining long term cell cultures, including those of human origin.
- With appropriate training must be able to independently analyze data, record data, prepare summary documents, and report data (written and oral) as needed.
- Timely, accurate and compliant entry of experimental data into Electronic Laboratory Notebook (ELN)
- Perform LC-MS/MS quantitation of samples in a setting of discovery bioanalysis. This may include method development, validation, and conducting sample analysis.
- Perform laboratory experiments with radioactive compounds in a safe and compliant manner.
- Knowledge of applicable regulatory guidelines and appropriate SOP trainings.
- Write/contribute to reports for regulatory filings as needed.
- Provide training to other scientists as required.
Qualifications (Minimal acceptable level of education, work experience, and competency)
·BS/MS degree in Life Sciences or equivalent experience.
·DMPK knowledge and experience in the biopharmaceutical or life sciences industry.
Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.
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