MSD Senior Scientist Target Biology & Screening 

Singapore, Singapore 

187664070

Job Description

As a Senior Scientist, you are expected to possess strong background in molecular and cell biology, with preferably experience in development of complex cell-based co-culture models using cell lines, patient-derived primary cells or induced pluripotent stem cells (iPSCs). You will work as part of a cross-functional team driving early drug discovery programs across multiple target classes, modalities, and therapeutic areas. You will be responsible for designing, executing, optimizing, and validating biochemical, cell-based, high content imaging-based assays according to industry standards to drive drug screening programs. You are expected to have hands-on experience in a variety of basic laboratory skills, applying understanding of underlying biological mechanisms and assay principles to develop fit-for-purpose

What You Will Do:

Drive design of experiments, development, optimization and validation of

standard and complex biochemical and translational cellular assays for target validation and small-scale screening studies across diverse therapeutic diseases and modalities by performing wet lab experiments as needed.

Proactively suggest new research ideas and demonstrating creative thinking, problem solving skills to develop and execute fit-for purpose assays to enable further understanding of disease biology, target engagement, pharmacodynamic responses and therapeutic mechanism of action.

Drive the optimization of induced pluripotent stem cell (iPSCs) expansion and differentiation, qualification and characterization methodologies to enable development of robust iPSC model build and high throughput iPSC drug screens.

Support and participate in various lab management and environment, health, safety initiatives as needed, including performing regular basic maintenance and quality control of equipment and serving as primary point of contact for equipment troubleshooting.

What You Must Have

Recent PhD in CellBiology/Biochemistry/Pharmacology,MSc in a Life Science-related discipline with more than five years of relevant research experience or BSc with a minimum of 8 years of relevant experience in automation and in vitro high throughput screens and assay development.

Experience designing, executing, and validating in vitro biophysical, biochemical, molecular, cellular assays using a wide range of modern technologies and quantitative detection methods.

Strong track record in assay development, optimization, and troubleshooting.

Experience developing robust automation protocols for high throughput drug screens using state-of-art liquid handling platforms such as ECHO, BRAVO, Tecan, etc. is a plus.

Good working knowledge and hands-on experience in cell culture and bio sample preparation, including 2D mammalian cell lines, iPSC-derived models, primary cell culture, 3D organotypic cultures.

Experience with high-content assay development, miniaturization and automation protocols to enable high throughput studies using automated image analysis tools, algorithms and data analysis is a plus.

Demonstrable 3D tissue modelling experience (e.g. spheroids, organoids, hydrogels, bio-scaffolds, organ-on-a-chips or bioprinting-based tissue models) is highly desired but not mandatory.

Strong understanding of cell biology and molecular biology is required. Knowledge in cancer, neuroscience, immunology and/or cardiometabolic disease biology is highly desired.

Solid organizational, experimental design, troubleshooting and data analysis skills, particularly knowledge in pharmacological data analysis is expected.

What You Can Expect

A supportive working environment that fosters career growth, continuous learning and diversity, equity, and inclusion.

Current Contingent Workers apply

Temporary (Fixed Term)

Not Applicable

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